Apolipoprotein E DNA methylation and late-life disease.

ABSTRACT: BACKGROUND:This study aims to investigate if DNA methylation of the apolipoprotein E (APOE) locus affects the risks of dementia, Alzheimeŕs disease (AD) or cardiovascular disease (CVD). METHODS:DNA methylation across the APOE gene has previously been categorized into three distinct regions: a hypermethylated region in the promoter, a hypomethylated region in the first two introns and exons and a hypermethylated region in the 3'exon that also harbours the APOE ε2 and ε4 alleles. DNA methylation levels in leukocytes were measured using the Illumina 450K array in 447 Swedish twins (mean age 78.1 years). We used logistic regression to investigate whether methylation levels in those regions affect the odds of disease. RESULTS:We found that methylation levels in the promoter region were associat

SUBMITTER: Karlsson IK 

PROVIDER: S-EPMC7263750 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature