Insights and Implications of Genome-Wide Association Studies of Height.

ABSTRACT:

Context

In the last decade, genome-wide association studies (GWASs) have catalyzed our understanding of the genetics of height and have identified hundreds of regions of the genome associated with adult height and other height-related body measurements.

Evidence acquisition

GWASs related to height were identified via PubMed search and a review of the GWAS catalog.

Evidence synthesis

The GWAS results demonstrate that height is highly polygenic: that is, many thousands of genetic variants distributed across the genome each contribute to an individual's height. These height-associated regions of the genome are enriched for genes in known biological pathways involved in growth, such as fibroblast growth factor signaling, as well as for genes expressed in relevant tissues,

SUBMITTER: Guo MH 

PROVIDER: S-EPMC7263788 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature