Portable capillary liquid chromatography for pharmaceutical and illicit drug analysis.

ABSTRACT: A newly developed portable capillary liquid chromatograph was investigated for the separation of various pharmaceutical and illicit drug compounds. The system consists of two high-pressure syringe pumps capable of delivering capillary-scale flow rates at pressures up to 10 000 psi. Capillary liquid chromatography columns packed with sub-2 μm particles are housed in cartridges that can be inserted into the system and easily connected through high-pressure fluidic contact points by simply applying a specific, predetermined torque rather than using standard fittings and less precise sealing protocols. Several over-the-counter analgesic drug separations are demonstrated, along with a simple online measurement of tablet dissolution. Twenty illicit drug compounds were also separated across six t

SUBMITTER: Foster SW 

PROVIDER: S-EPMC7263832 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature