Diffusion-time dependence of diffusional kurtosis in the mouse brain.

ABSTRACT:

Purpose

To investigate diffusion-time dependency of diffusional kurtosis in the mouse brain using pulsed-gradient spin-echo (PGSE) and oscillating-gradient spin-echo (OGSE) sequences.

Methods

3D PGSE and OGSE kurtosis tensor data were acquired from ex vivo brains of adult, cuprizone-treated, and age-matched control mice with diffusion-time (t_D ) ~ 20 ms and frequency (f) = 70 Hz, respectively. Further, 2D acquisitions were performed at multiple times/frequencies ranging from f = 140 Hz to t_D = 30 ms with b-values up to 4000 s/mm² . Monte Carlo simulations were used to investigate the coupled effects of varying restriction size and permeability on time/frequency-dependence of kurtosis with both diffusion-encoding schemes. Simulations and exper

SUBMITTER: Aggarwal M 

PROVIDER: S-EPMC7263939 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature