Chronic pain in children: structural and resting-state functional brain imaging within a developmental perspective.

ABSTRACT: Chronic pain is a major public health problem in the United States costing $635 billion annually. Hospitalizations for chronic pain in childhood have increased almost tenfold in the past decade, without breakthroughs in novel treatment strategies. Findings from brain imaging studies using structural and resting-state fMRI could potentially help personalize treatment to address this costly and prevalent health problem by identifying the underlying brain pathways that contribute, facilitate, and maintain chronic pain. The aim of this review is to synthesize structural and resting-state network pathology identified by recent brain imaging studies in pediatric chronic pain populations and discuss the potential impact of chronic pain on cortical development. Sex differences as well as treatment

SUBMITTER: Bhatt RR 

PROVIDER: S-EPMC7263945 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature