Impact of perioperative blood transfusion on survival in pancreatic neuroendocrine tumor patients: analysis from the US Neuroendocrine Study Group.

ABSTRACT:

Background

Packed red blood cell (PRBC) transfusion has been associated with worse survival in multiple malignancies but its impact on pancreatic neuroendocrine tumors (PNETs) is unknown. The aim of this study was to determine the impact of PRBC transfusion on survival following PNET resection.

Methods

A retrospective cohort study of PNET patients was performed using the US Neuroendocrine Tumor Study Group database. Demographic and clinical factors were compared. Kaplan-Meier and log-rank analyses were performed. Factors associated with transfusion, overall (OS), recurrence-free (RFS) and progression-free survival (PFS) were assessed by logistic regression.

Results

Of 1129 patients with surgically resected PNETs, 156 (13.8%) received perioperative PRBC transfusion. Tr

SUBMITTER: Marincola Smith P 

PROVIDER: S-EPMC7263954 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature