A randomized placebo-controlled trial of bupropion for Cancer-related fatigue: Study design and procedures.

ABSTRACT:

Background

Cancer-related fatigue is a significant problem and is associated with poor quality of life. Behavioral interventions include exercise and cognitive-behavioral therapy, which survivors may be unwilling or unable to adopt. Pharmacologic interventions (e.g., selective serotonin reuptake inhibitors) have been disappointing. One potential therapy is the antidepressant bupropion, a norepinephrine-dopamine reuptake inhibitor that targets both inflammation and the hypothalamic-pituitary-adrenal axis. The current study is intended to provide a rigorous test of the efficacy and tolerability of bupropion for cancer-related fatigue.

Methods

A randomized, double-blind, placebo-controlled trial will examine the effects of bupropion on cancer-related fatigue. The trial will be

SUBMITTER: Jim HSL 

PROVIDER: S-EPMC7263969 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature