Delayed tooth movement in Runx2^+/- mice associated with mTORC2 in stretch-induced bone formation.

ABSTRACT: Runt-related transcription factor 2 (Runx2) is an essential transcription factor for osteoblast differentiation, and is activated by mechanical stress to promote osteoblast function. Cleidocranial dysplasia (CCD) is caused by mutations of RUNX2, and CCD patients exhibit malocclusion and often need orthodontic treatment. However, treatment is difficult because of impaired tooth movement, the reason of which has not been clarified. We examined the amount of experimental tooth movement in Runx2^+/- mice, the animal model of CCD, and investigated bone formation on the tension side of experimental tooth movement in vivo. Continuous stretch was conducted to bone marrow stromal cells (BMSCs) as an in vitro model of the tension side of tooth movement. Compared to wil

SUBMITTER: Aonuma T 

PROVIDER: S-EPMC7264061 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature