Wntless regulates lipogenic gene expression in adipocytes and protects against diet-induced metabolic dysfunction.

ABSTRACT:

Objective

Obesity is a key risk factor for many secondary chronic illnesses, including type 2 diabetes and cardiovascular disease. Canonical Wnt/β-catenin signaling is established as an important endogenous inhibitor of adipogenesis. This pathway is operative in mature adipocytes; however, its roles in this context remain unclear due to complexities of Wnt signaling and differences in experimental models. In this study, we used novel cultured cell and mouse models to investigate functional roles of Wnts secreted from adipocytes.

Methods

We generated adipocyte-specific Wntless (Wls) knockout mice and cultured cell models to investigate molecular and metabolic consequences of disrupting Wnt secretion from mature adipocytes. To characterize Wls-deficient cultured adipocytes, we

SUBMITTER: Bagchi DP 

PROVIDER: S-EPMC7264081 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature