Brain Functional and Structural Signatures in Parkinson's Disease.

ABSTRACT: The aim of this study is to explore functional and structural properties of abnormal brain networks associated with Parkinson's disease (PD). ¹⁸F-Fluorodeoxyglucose positron emission tomography (¹⁸F-FDG PET) and T1-weighted magnetic resonance imaging from 20 patients with moderate-stage PD and 20 age-matched healthy controls were acquired to identify disease-related patterns in functional and structural networks. Dual-modal images from another prospective subject of 15 PD patients were used as the validation group. Scaled Subprofile Modeling based on principal component analysis method was applied to determine disease-related patterns in both modalities, and brain connectome analysis based on graph theory was applied to verify these patterns. The results showed that t

SUBMITTER: Liu C 

PROVIDER: S-EPMC7264099 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature