Optimizing an Injectable Composite Oxygen-Generating System for Relieving Tissue Hypoxia.

ABSTRACT: Oxygen deficiency resulting from bone fracture-induced vascular disruption leads to massive cell death and delayed osteoblast differentiation, ultimately impairing new bone formation and fracture healing. Enhancing local tissue oxygenation can help promote bone regeneration. In this work, an injectable composite oxygen-generating system consisting of calcium peroxide (CaO₂)/manganese dioxide (MnO₂)-encapsulated poly lactic-co-glycolic acid (PLGA) microparticles (CaO₂ + MnO₂@PLGA MPs) is proposed for the local delivery of oxygen. By utilizing a series of methodologies, the impacts of each component used for MP fabrication on the oxygen release behavior and cytotoxicity of the CaO₂ + MnO₂@ PLGA MPs are thoroughly invest

SUBMITTER: Hsieh TE 

PROVIDER: S-EPMC7264163 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature