A computational drug repositioning method applied to rare diseases: Adrenocortical carcinoma.

ABSTRACT: Rare or orphan diseases affect only small populations, thereby limiting the economic incentive for the drug development process, often resulting in a lack of progress towards treatment. Drug repositioning is a promising approach in these cases, due to its low cost. In this approach, one attempts to identify new purposes for existing drugs that have already been developed and approved for use. By applying the process of drug repositioning to identify novel treatments for rare diseases, we can overcome the lack of economic incentives and make concrete progress towards new therapies. Adrenocortical Carcinoma (ACC) is a rare disease with no practical and definitive therapeutic approach. We apply Heter-LP, a new method of drug repositioning, to suggest novel therapeutic avenues for ACC. Our ana

SUBMITTER: Lotfi Shahreza M 

PROVIDER: S-EPMC7264316 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature