Integrating whole-genome sequencing within the National Antimicrobial Resistance Surveillance Program in the Philippines.

ABSTRACT: National networks of laboratory-based surveillance of antimicrobial resistance (AMR) monitor resistance trends and disseminate these data to AMR stakeholders. Whole-genome sequencing (WGS) can support surveillance by pinpointing resistance mechanisms and uncovering transmission patterns. However, genomic surveillance is rare in low- and middle-income countries. Here, we implement WGS within the established Antimicrobial Resistance Surveillance Program of the Philippines via a binational collaboration. In parallel, we characterize bacterial populations of key bug-drug combinations via a retrospective sequencing survey. By linking the resistance phenotypes to genomic data, we reveal the interplay of genetic lineages (strains), AMR mechanisms, and AMR vehicles underlying the expansion of spec

SUBMITTER: Argimon S 

PROVIDER: S-EPMC7264328 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature