The Keloid Disorder: Heterogeneity, Histopathology, Mechanisms and Models.

ABSTRACT: Keloids constitute an abnormal fibroproliferative wound healing response in which raised scar tissue grows excessively and invasively beyond the original wound borders. This review provides a comprehensive overview of several important themes in keloid research: namely keloid histopathology, heterogeneity, pathogenesis, and model systems. Although keloidal collagen versus nodules and α-SMA-immunoreactivity have been considered pathognomonic for keloids versus hypertrophic scars, conflicting results have been reported which will be discussed together with other histopathological keloid characteristics. Importantly, histopathological keloid abnormalities are also present in the keloid epidermis. Heterogeneity between and within keloids exists which is often not considered when interpreting r

SUBMITTER: Limandjaja GC 

PROVIDER: S-EPMC7264387 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature