A Tractable Drosophila Cell System Enables Rapid Identification of Acinetobacter baumannii Host Factors.

ABSTRACT: Acinetobacter baumannii is an important causative agent of nosocomial infections worldwide. The pathogen also readily acquires resistance to antibiotics, and pan-resistant strains have been reported. A. baumannii is widely regarded as an extracellular bacterial pathogen. However, accumulating evidence demonstrates that the pathogen can invade, survive or persist in infected mammalian cells. Unfortunately, the molecular mechanisms controlling these processes remain poorly understood. Here, we show that Drosophila S2 cells provide several attractive advantages as a model system for investigating the intracellular lifestyle of the pathogen, including susceptibility to bacterial intracellular replication and limited infection-induced host cell death. We also show that the

SUBMITTER: Qin QM 

PROVIDER: S-EPMC7264411 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature