MICA ^∗012:01 Allele Facilitates the Metastasis of KRAS-Mutant Colorectal Cancer.

ABSTRACT: Major histocompatibility complex (HLA) class I chain-related protein A (MICA) regulates immune surveillance through activation of NKG2D (natural killer group 2D) receptor. However, the genetic association, potential function, and predictive ability of MICA alleles with colorectal cancer (CRC) prognosis remain undefined. In this study, we characterized MICA alleles in tissue samples from 104 patients with CRC and 536 healthy controls and carried out genetic association studies by molecular and clinical CRC phenotypes. Preliminary sequence analysis revealed that MICA ^∗009:01 or ^∗049 alleles were significantly decreased in patients with CRC (p = 0.0049), and further stratification analysis indicated that MICA ^∗012:01 allele was asso

SUBMITTER: Ding W 

PROVIDER: S-EPMC7264413 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature