Non-invasive Reporter Gene Imaging of Cell Therapies, including T Cells and Stem Cells.

ABSTRACT: Cell therapies represent a rapidly emerging class of new therapeutics. They are intended and developed for the treatment of some of the most prevalent human diseases, including cancer, diabetes, and for regenerative medicine. Currently, they are largely developed without precise assessment of their in vivo distribution, efficacy, or survival either clinically or preclinically. However, it would be highly beneficial for both preclinical cell therapy development and subsequent clinical use to assess these parameters in situ to enable enhancements in efficacy, applicability, and safety. Molecular imaging can be exploited to track cells non-invasively on the whole-body level and can enable monitoring for prolonged periods in a manner compatible with rapidly expanding cell types. In this review

SUBMITTER: Ashmore-Harris C 

PROVIDER: S-EPMC7264441 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature