Has the introduction of direct oral anticoagulants (DOACs) in England increased emergency admissions for bleeding conditions? A longitudinal ecological study.

ABSTRACT:

Objective

There is concern about long-term safety of direct oral coagulants (DOACs) in clinical practice. Our aim was to investigate whether the introduction of DOACs compared with vitamin-K antagonists in England was associated with a change in admissions for bleeding or thromboembolic complications.

Setting

5508 General practitioner (GP) practices in England between 2011 and 2016.

Participants

All GP practices in England with a registered population size of greater than 1000 that had data for all 6 years.

Main outcome measure

The rate of emergency admissions to hospital for bleeding or thromboembolism, per 100 000 population for each GP practice in England.

Main exposure measure

The annual number of DOAC items prescribed for each GP practice population

SUBMITTER: Alfirevic A 

PROVIDER: S-EPMC7264699 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature