Intercellular Sodium Regulates Repolarization in Cardiac Tissue with Sodium Channel Gain of Function.

ABSTRACT: In cardiac myocytes, action potentials are initiated by an influx of sodium (Na⁺) ions via voltage-gated Na⁺ channels. Na⁺ channel gain of function (GOF), arising in both inherited conditions associated with mutation in the gene encoding the Na⁺ channel and acquired conditions associated with heart failure, ischemia, and atrial fibrillation, enhance Na⁺ influx, generating a late Na⁺ current that prolongs action potential duration (APD) and triggering proarrhythmic early afterdepolarizations (EADs). Recent studies have shown that Na⁺ channels are highly clustered at the myocyte intercalated disk, facilitating formation of Na⁺ nanodomains in the intercellular cleft between cells. Simulations from our grou

SUBMITTER: Nowak MB 

PROVIDER: S-EPMC7264809 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature