Dataset Information

Extreme neonatal hyperbilirubinaemia in refugee and migrant populations: retrospective cohort.

ABSTRACT:

Objective

To describe neonatal survival and long-term neurological outcome in neonatal hyperbilirubinaemia (NH) with extreme serum bilirubin (SBR) values.

Design

Retrospective chart review, a one-off neurodevelopmental evaluation.

Setting

Special care baby unit in a refugee camp and clinics for migrant populations at the Thailand-Myanmar border with phototherapy facilities but limited access to exchange transfusion (ET).

Patients

Neonates ≥28 weeks of gestational age with extreme SBR values and/or acute neurological symptoms, neurodevelopment evaluation conducted at 23-97 months of age.

Main outcome measures

Neonatal mortality rate, prevalence of acute bilirubin encephalopathy (ABE) signs, prevalence of delayed development scores based on the Griffiths Mental Development Scale (GMDS).

Results

From 2009 to 2014, 1946 neonates were diagnosed with jaundice; 129 (6.6%) had extreme SBR values during NH (extreme NH). In this group, the median peak SBR was 430 (IQR 371-487) µmol/L and the prevalence of ABE was 28.2%. Extreme NH-related mortality was 10.9% (14/129). Median percentile GMDS general score of 37 survivors of extreme NH was poor: 11 (2-42). 'Performance', 'practical reasoning' and 'hearing and language' domains were most affected. Four (10.8%) extreme NH survivors had normal development scores (≥50th centile). Two (5.4%) developed the most severe form of kernicterus spectrum disorders.

Conclusion

In this limited-resource setting, poor neonatal survival and neurodevelopmental outcomes, after extreme NH, were high. Early identification and adequate treatment of NH where ET is not readily available are key to minimising the risk of extreme SBR values or neurological symptoms.

SUBMITTER: Wouda EMN

PROVIDER: S-EPMC7264833 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Extreme neonatal hyperbilirubinaemia in refugee and migrant populations: retrospective cohort.

Wouda Eva Maria Nadine EMN Thielemans Laurence L Darakamon Mue Chae MC Nge Aye Aye AA Say Wah W Khing Sanda S Hanboonkunupakarn Borimas B Ngerseng Thatsanun T Landier Jordi J van Rheenen Patrick Ferry PF Turner Claudia C Nosten Francois F McGready Rose R Carrara Verena Ilona VI

BMJ paediatrics open 20200528 1

<h4>Objective</h4>To describe neonatal survival and long-term neurological outcome in neonatal hyperbilirubinaemia (NH) with extreme serum bilirubin (SBR) values.<h4>Design</h4>Retrospective chart review, a one-off neurodevelopmental evaluation.<h4>Setting</h4>Special care baby unit in a refugee camp and clinics for migrant populations at the Thailand-Myanmar border with phototherapy facilities but limited access to exchange transfusion (ET).<h4>Patients</h4>Neonates ≥28 weeks of gestational age ...[more]

PMID: 32537522

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Dataset Information

Extreme neonatal hyperbilirubinaemia in refugee and migrant populations: retrospective cohort.

Objective

Design

Setting

Patients

Main outcome measures

Results

Conclusion

Publications

Extreme neonatal hyperbilirubinaemia in refugee and migrant populations: retrospective cohort.

Similar Datasets

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