Increased weight loading reduces body weight and body fat in obese subjects - A proof of concept randomized clinical trial.

ABSTRACT:

Background

Recently we provided evidence for a leptin-independent homeostatic regulation, the gravitostat, of body weight in rodents. The aim of the present translational proof of concept study was to test the gravitostat hypothesis in humans.

Methods

We conducted a randomized controlled single center trial (ClinicalTrial.gov number, NCT03672903), to evaluate the efficacy of artificially increased weight loading on body weight in subjects with mild obesity (BMI 30-35 kg/m²). Subjects were either treated with a heavy (=high load; 11% of body weight) or light (=low load; 1% of body weight) weight vest for eight hours per day for three weeks. The primary outcome was change in body weight. Secondary outcomes included change in body fat mass and fat-free mass as

SUBMITTER: Ohlsson C 

PROVIDER: S-EPMC7264953 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature