The rs6265 Polymorphism of the BDNF Gene Is Related to Higher-Lethality Suicide Attempts in the Korean Population.

ABSTRACT: OBJECTIVE:Since the risk of suicide cannot be predicted by clinical symptoms alone, and suicide is known to have a genetic component, the discovery of genetic markers that can predict the lethality of suicide attempts is a clinically important topic. There have been many studies aiming to determine whether the rs6265 polymorphism of the BDNF gene is associated with suicidality; however, the results have been mixed, and there have been few studies investigating the relationship between this polymorphism and suicide attempt lethality. METHODS:We assessed suicide lethality in 258 individuals who had attempted suicide using the relative risk ratio (RRR) scale and by genotyping the rs6265 polymorphism of the BDNF gene. RESULTS:The RRR score for suicide attempts was higher in subjects with Met/V

SUBMITTER: Kang SG 

PROVIDER: S-EPMC7265018 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature