Sleeve gastrectomy ameliorates endothelial function and prevents lung cancer by normalizing endothelin-1 axis in obese and diabetic rats.

ABSTRACT:

Background

Previous evidence has implied that obesity is an independent risk factor for developing cancer. Being closely related to obesity, type 2 diabetes mellitus provides a suitable environment for the formation and metastasis of tumors through multiple pathways. Although bariatric surgeries are effective in preventing and lowering the risk of various types of cancer, the underlying mechanisms of this effect are not clearly elucidated.

Aim

To uncover the role and effect of sleeve gastrectomy (SG) in preventing lung cancer in obese and diabetic rats.

Methods

SG was performed on obese and diabetic Wistar rats, and the postoperative transcriptional and translational alterations of the endothelin-1 (ET-1) axis in the lungs were compared to sham-operated obese and diab

SUBMITTER: Ruze R 

PROVIDER: S-EPMC7265138 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature