Conservation and variability of hepatitis B core at different chronic hepatitis stages.

ABSTRACT:

Background

Since it is currently not possible to eradicate hepatitis B virus (HBV) infection with existing treatments, research continues to uncover new therapeutic strategies. HBV core protein, encoded by the HBV core gene (HBC), intervenes in both structural and functional processes, and is a key protein in the HBV life cycle. For this reason, both the protein and the gene could be valuable targets for new therapeutic and diagnostic strategies. Moreover, alterations in the protein sequence could serve as potential markers of disease progression.

Aim

To detect, by next-generation sequencing, HBC hyper-conserved regions that could potentially be prognostic factors and targets for new therapies.

Methods

Thirty-eight of 45 patients with chronic HBV initial

SUBMITTER: Yll M 

PROVIDER: S-EPMC7265140 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature