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Role of γδT cells in liver diseases and its relationship with intestinal microbiota.

ABSTRACT: γδT cells are unconventional T lymphocytes that bridge innate and adaptive immunity. Based on the composition of T cell receptor and the cytokines produced, γδT cells can be divided into diverse subsets that may be present at different locations, including the liver, epithelial layer of the gut, the dermis and so on. Many of these cells perform specific functions in liver diseases, such as viral hepatitis, autoimmune liver diseases, non-alcoholic fatty liver disease, liver cirrhosis and liver cancers. In this review, we discuss the distribution, subsets, functions of γδT cells and the relationship between the microbiota and γδT cells in common hepatic diseases. As γδT cells have been used to cure hematological and solid tumors, we are interested in γδT cell-based immunotherapies to treat liver diseases.

SUBMITTER: Zhou QH

PROVIDER: S-EPMC7265152 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Role of γδT cells in liver diseases and its relationship with intestinal microbiota.

Zhou Qi-Hui QH Wu Feng-Tian FT Pang Lan-Tian LT Zhang Tian-Bao TB Chen Zhi Z

World journal of gastroenterology 20200501 20

γδT cells are unconventional T lymphocytes that bridge innate and adaptive immunity. Based on the composition of T cell receptor and the cytokines produced, γδT cells can be divided into diverse subsets that may be present at different locations, including the liver, epithelial layer of the gut, the dermis and so on. Many of these cells perform specific functions in liver diseases, such as viral hepatitis, autoimmune liver diseases, non-alcoholic fatty liver disease, liver cirrhosis and liver ca ...[more]

PMID: 32523311

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