Notch signaling in mouse blastocyst development and hatching.

ABSTRACT:

Background

Mammalian early embryo development requires a well-orchestrated interplay of cell signaling pathways. Notch is a major regulatory pathway involved in cell-fate determination in embryonic and adult scenarios. However, the role of Notch in embryonic pre-implantation development is controversial. In particular, Notch role on blastocyst development and hatching remains elusive, and a complete picture of the transcription and expression patterns of Notch components during this time-period is not available.

Results

This study provided a comprehensive view on the dynamics of individual embryo gene transcription and protein expression patterns of Notch components (receptors Notch1-4; ligands Dll1 and Dll4, Jagged1-2; and effectors Hes1-2), and their relationship with tran

SUBMITTER: Batista MR 

PROVIDER: S-EPMC7265256 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature