Host genotype and exercise exhibit species-level selection for members of the gut bacterial communities in the mouse digestive system.

ABSTRACT: The mammalian gut microbiome can potentially impact host health and disease state. It is known that the mouse-genome, eating-behavior, and exercise-status promotes higher taxonomic rank-level alterations (e.g. family to phyla-level) of the gut microbiota. Here, host genotype or activity status was investigated to determine if selection of individual bacterial species or strains could be discerned within the murine digestive system. For this study, the fecal bacterial community of adenylyl cyclase 5 knock-out (AC5KO, n = 7) mice or their wild-type (WT, n = 10) littermates under exercise or sedentary conditions were profiled by sequencing rRNA operons. AC5KO mice were chosen since this genotype displays enhanced longevity/exercise capacity and protects against cardiovascular/metabolic diseas

SUBMITTER: Dowden RA 

PROVIDER: S-EPMC7265280 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature