MTOR-Myc axis drives acinar-to-dendritic cell transition and the CD4⁺ T cell immune response in acute pancreatitis.

ABSTRACT: The inflammatory response in acute pancreatitis (AP) is associated with acinar-to-dendritic cell transition. The CD4⁺ T-cell-mediated adaptive immune response is necessary for pancreatic inflammatory damage. However, the effect of acinar-to-dendritic cell transition on the CD4⁺ T-cell response and the regulatory mechanism remain undefined. A mouse animal model of AP was established by repeated intraperitoneal injection of CAE. The mTOR inhibitor rapamycin was administered before AP induction. Primary acinar cells were isolated and co-incubated with subsets of differentiated CD4⁺ T cells. The expression of DC-SIGN was also assessed in pancreatic tissues from human AP patients. We found acinar cells expressed DC-SIGN and displayed the phenotype of dendritic c

SUBMITTER: Xu D 

PROVIDER: S-EPMC7265283 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature