Mitochondrial translation and dynamics synergistically extend lifespan in C. elegans through HLH-30.

ABSTRACT: Mitochondrial form and function are closely interlinked in homeostasis and aging. Inhibiting mitochondrial translation is known to increase lifespan in C. elegans, and is accompanied by a fragmented mitochondrial network. However, whether this link between mitochondrial translation and morphology is causal in longevity remains uncharacterized. Here, we show in C. elegans that disrupting mitochondrial network homeostasis by blocking fission or fusion synergizes with reduced mitochondrial translation to prolong lifespan and stimulate stress response such as the mitochondrial unfolded protein response, UPRMT. Conversely, immobilizing the mitochondrial network through a simultaneous disruption of fission and fusion abrogates the lifespan increase induced by mitochondrial translation inhibition

SUBMITTER: Liu YJ 

PROVIDER: S-EPMC7265311 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature