Elite control of HIV is associated with distinct functional and transcriptional signatures in lymphoid tissue CD8⁺ T cells.

ABSTRACT: The functional properties of circulating CD8⁺ T cells have been associated with immune control of HIV. However, viral replication occurs predominantly in secondary lymphoid tissues, such as lymph nodes (LNs). We used an integrated single-cell approach to characterize effective HIV-specific CD8⁺ T cell responses in the LNs of elite controllers (ECs), defined as individuals who suppress viral replication in the absence of antiretroviral therapy (ART). Higher frequencies of total memory and follicle-homing HIV-specific CD8⁺ T cells were detected in the LNs of ECs compared with the LNs of chronic progressors (CPs) who were not receiving ART. Moreover, HIV-specific CD8⁺ T cells potently suppressed viral replication without demonstrable cytolytic activ

SUBMITTER: Nguyen S 

PROVIDER: S-EPMC7265335 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature