Role of Androgen Receptor for Reconsidering the "True" Polycystic Ovarian Morphology in PCOS.

ABSTRACT:

Purpose

Polycystic ovarian morphology (PCOM) is one of the key features of polycystic ovary syndrome (PCOS). The diagnosis of PCOM according to the Rotterdam criteria (≥12 antral follicles per ovary) is debated because of the high prevalence of PCOM in the general population. Androgen receptor (AR) is associated with the PCOS phenotype and might as well play a role during folliculogenesis. This study is aimed to investigate the expression of the AR in PCOS granulosa cells (GCs) and its relationship with the PCOM phenotype.

Methods

106 PCOS cases and 63 controls were included from the Center for Reproductive Medicine, Shandong University. The diagnosis of PCOS was following the Rotterdam criteria (2003). Total RNA was extracted from GCs retrieved from ovarian stimulation. The

SUBMITTER: Gao XY 

PROVIDER: S-EPMC7265442 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature