TNF-alpha-induced microglia activation requires miR-342: impact on NF-kB signaling and neurotoxicity.

ABSTRACT: Growing evidences suggest that sustained neuroinflammation, caused by microglia overactivation, is implicated in the development and aggravation of several neurological and psychiatric disorders. In some pathological conditions, microglia produce increased levels of cytotoxic and inflammatory mediators, such as tumor necrosis factor alpha (TNF-α), which can reactivate microglia in a positive feedback mechanism. However, specific molecular mediators that can be effectively targeted to control TNF-α-mediated microglia overactivation, are yet to be uncovered. In this context, we aim to identify novel TNF-α-mediated micro(mi)RNAs and to dissect their roles in microglia activation, as well as to explore their impact on the cellular communication with neurons. A miRNA microarray, followed by RT-

SUBMITTER: Bras JP 

PROVIDER: S-EPMC7265562 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature