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Regression of Papillary Thyroid Cancer during Nivolumab for Renal Cell Cancer.

ABSTRACT: Immune checkpoint inhibitors have been recently approved for cancer treatment. Nivolumab is a monoclonal antibody specific for programmed cell death-1 (PD-1) that modulates T-cell response. It was initially used for the treatment of malignant melanoma and then approved in other cancers, such as non-small cell lung cancer and clear cell renal cell carcinoma (ccRCC). So far, the activity of nivolumab in patients with thyroid malignancies has been reported in a single case of anaplastic thyroid cancer. Here, we report the case of a patient with ccRCC who developed a papillary thyroid carcinoma (PTC) under first-line sunitinib treatment. During nivolumab, the second-line treatment for ccRCC, we unexpectedly observed a complete regression of PTC.

SUBMITTER: Palermo A

PROVIDER: S-EPMC7265713 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Regression of Papillary Thyroid Cancer during Nivolumab for Renal Cell Cancer.

Palermo Andrea A Napolitano Andrea A Maggi Daria D Naciu Anda Mihaela AM Tabacco Gaia G Manfrini Silvia S Crescenzi Anna A Taffon Chiara C Pantano Francesco F Vincenzi Bruno B Tonini Guiseppe G Santini Daniele D

European thyroid journal 20200415 3

Immune checkpoint inhibitors have been recently approved for cancer treatment. Nivolumab is a monoclonal antibody specific for programmed cell death-1 (PD-1) that modulates T-cell response. It was initially used for the treatment of malignant melanoma and then approved in other cancers, such as non-small cell lung cancer and clear cell renal cell carcinoma (ccRCC). So far, the activity of nivolumab in patients with thyroid malignancies has been reported in a single case of anaplastic thyroid can ...[more]

PMID: 32523892

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