Comparison of diagnostic accuracies of rapid serological tests and ELISA to molecular diagnostics in patients with suspected coronavirus disease 2019 presenting to the hospital.

ABSTRACT:

Objectives

To assess the diagnostic performance of rapid lateral flow immunochromatographic assays (LFAs) compared with an ELISA and nucleic acid amplification tests (NATs) in individuals with suspected coronavirus disease 2019 (COVID-19).

Methods

Patients presenting to a Dutch teaching hospital were eligible between 17 March and 10 April 2020, when they had respiratory symptoms that were suspected for COVID-19. The performances of six different LFAs were evaluated in plasma samples obtained on corresponding respiratory sample dates of NATs testing. Subsequently, the best performing LFA was evaluated in 228 patients and in 50 sera of a historical patient control group.

Results

In the pilot analysis, sensitivity characteristics of LFA were heterogeneous, ranging from 2

SUBMITTER: Ong DSY 

PROVIDER: S-EPMC7265854 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature