TRPV1-Estradiol Stereospecific Relationship Underlies Cell Survival in Oxidative Cell Death.

ABSTRACT: 17β-estradiol is a neuronal survival factor against oxidative stress that triggers its protective effect even in the absence of classical estrogen receptors. The polymodal transient receptor potential vanilloid subtype 1 (TRPV1) channel has been proposed as a steroid receptor implied in tissue protection against oxidative damage. We show here that TRPV1 is sufficient condition for 17β-estradiol to enhance metabolic performance in injured cells. Specifically, in TRPV1 expressing cells, the application of 17β-estradiol within the first 3 h avoided H₂O₂-dependent mitochondrial depolarization and the activation of caspase 3/7 protecting against the irreversible damage triggered by H₂O₂. Furthermore, 17β-estradiol potentiates TRPV1 single channel acti

SUBMITTER: Ramirez-Barrantes R 

PROVIDER: S-EPMC7265966 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature