P2Y₁₂ inhibitors with oral anticoagulation for percutaneous coronary intervention with atrial fibrillation: a systematic review and meta-analysis.

ABSTRACT:

Objective

This study aimed to compare the safety and efficacy of third-generation P2Y₁₂ inhibitors versus clopidogrel in combination with oral anticoagulation (OAC) with or without aspirin in patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI).

Methods

We performed a systematic review including both prospective and retrospective studies that compared dual and triple antithrombotic regimens for bleeding and major adverse cardiac events (MACE) in patients with AF undergoing PCI. We analysed rates of bleeding and MACE by P2Y₁₂ inhibitor choice. Risk ratio (RR) 95% CIs were measured using the Mantel-Haenszel method. Where study heterogeneity was low (I² <25%), we used the fixed effects model, otherwise the r

SUBMITTER: Lupercio F 

PROVIDER: S-EPMC7265981 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature