Host-vaginal microbiota interactions in the pathogenesis of bacterial vaginosis.

ABSTRACT:

Purpose of review

The cause of bacterial vaginosis, the most common cause of vaginal discharge in women, remains controversial. We recently published an updated conceptual model on bacterial vaginosis pathogenesis, focusing on the roles of Gardnerella vaginalis and Prevotella bivia as early colonizers and Atopobium vaginae and other bacterial vaginosis-associated bacteria (BVAB) as secondary colonizers in this infection. In this article, we extend the description of our model to include a discussion on the role of host-vaginal microbiota interactions in bacterial vaginosis pathogenesis.

Recent findings

Although G. vaginalis and P. bivia are highly abundant in women with bacterial vaginosis, neither induce a robust inflammatory response from vaginal epithelial cells. These ea

SUBMITTER: Muzny CA 

PROVIDER: S-EPMC7265982 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature