Precious cargo: Modulation of the mesenteric lymph exosome payload after hemorrhagic shock.

ABSTRACT:

Background

Trauma/hemorrhagic shock (T/HS) causes a release of proinflammatory mediators into the mesenteric lymph (ML) that may trigger a systemic inflammatory response and subsequent organ failure. Recently, we showed that exosomes in postshock ML are biologically active mediators of this inflammation. Because the specific inflammatory mediators in postshock ML exosomes have yet to be characterized, we hypothesized that T/HS would lead to a distinct ML proinflammatory exosome phenotype that could be identified by proteomic analysis. We further hypothesized that their regulation by the neuroenteric axis via the vagus nerve would modify this proinflammatory profile.

Methods

Male rats underwent an established T/HS model including 60 minutes of HS followed by resuscitation. Me

SUBMITTER: Williams EC 

PROVIDER: S-EPMC7265989 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature