Cadmium, Smoking, and Human Blood DNA Methylation Profiles in Adults from the Strong Heart Study.

ABSTRACT:

Background

The epigenetic effects of individual environmental toxicants in tobacco remain largely unexplored. Cadmium (Cd) has been associated with smoking-related health effects, and its concentration in tobacco smoke is higher in comparison with other metals.

Objectives

We studied the association of Cd and smoking exposures with human blood DNA methylation (DNAm) profiles. We also evaluated the implication of findings to relevant methylation pathways and the potential contribution of Cd exposure from smoking to explain the association between smoking and site-specific DNAm.

Methods

We conducted an epigenome-wide association study of urine Cd and self-reported smoking (current and former vs. never, and cumulative smoking dose) with blood DNAm in 790,026 CpGs (methyla

SUBMITTER: Domingo-Relloso A 

PROVIDER: S-EPMC7265996 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature