Impact of Huntington's Disease on Mental Rotation Performance in Motor Pre-Symptomatic Individuals.

ABSTRACT:

Background

Huntington's disease (HD) is a genetic disorder known for affecting motor control. Despite evidence for the impact of HD on visual cortico-striatal loops, evidence for impaired visual perception in early symptomatic HD patients is limited; much less is known about what happens during the HD prodrome.

Objective

The goals of this study were to evaluate perceptual processing in motor pre-manifest HD gene-carriers (Pre-HDs) during a visual mental rotation task.

Methods

To achieve this goal, 79 participants including 24 Pre-HD participants and 55 healthy matched controls were scanned using functional MRI as they performed a mental rotation task. Another group of 36 subjects including 15 pre-HDs and 21 healthy age/gender matched controls participated in a control

SUBMITTER: Nasr S 

PROVIDER: S-EPMC7266007 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature