Outcomes after hepatic encephalopathy in population-based cohorts of patients with cirrhosis.

ABSTRACT:

Background

Hepatic encephalopathy is a devastating complication of cirrhosis.

Aim

To describe the outcomes after developing hepatic encephalopathy among contemporary, aging patients.

Methods

We examined data for a 20% random sample of United States Medicare enrolees with cirrhosis and Part D prescription coverage from 2008 to 2014. Among 49 164 persons with hepatic encephalopathy, we evaluated the associations with transplant-free survival using Cox proportional hazard models with time-varying covariates (hazard ratios, HR) and incidence rate ratios (IRR) for healthcare utilisation measured in hospital-days and 30-day readmissions per person-year. We validated our findings in an external cohort of 2184 privately insured patients with complete laboratory values.

Res

SUBMITTER: Tapper EB 

PROVIDER: S-EPMC7266029 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature