Associations Between Microstructure, Amyloid, and Cognition in Amnestic Mild Cognitive Impairment and Dementia.

ABSTRACT:

Background

Although amyloid-β (Aβ) and microstructural brain changes are both effective biomarkers of Alzheimer's disease, their independent or synergistic effects on cognitive decline are unclear.

Objective

To examine associations of Aβ and brain microstructure with cognitive decline in amnestic mild cognitive impairment and dementia.

Methods

Restriction spectrum imaging, cerebrospinal fluid Aβ, and longitudinal cognitive data were collected on 23 healthy controls and 13 individuals with mild cognitive impairment or mild to moderate Alzheimer's disease. Neurite density (ND) and isotropic free water diffusion (IF) were computed in fiber tracts and cortical regions of interest. We examined associations of Aβ with regional and whole-brain microstructure, and assessed wh

SUBMITTER: Reas ET 

PROVIDER: S-EPMC7266036 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature