Increased β-Cell Responsivity Independent of Insulin Sensitivity in Healthy African American Adults.

ABSTRACT: Primary insulin hypersecretion predicts type 2 diabetes (T2DM) independent of insulin resistance. Enhanced β-cell glucose responsivity contributes to insulin hypersecretion. African Americans (AAs) are at a higher risk for T2DM than non-Hispanic Whites (NHWs). Whether AAs manifest primary insulin hypersecretion is an important topic that has not been examined systematically. To examine if nondiabetic AA adults have a higher β-cell glucose responsivity compared with NHWs. Healthy nondiabetic AA (n = 18) and NHW (n=18) subjects were prospectively recruited. Indices of β-cell function, acute C-peptide secretion (X0); basal (Φ B), first-phase (Φ 1), second-phase (Φ 2), and total β-cell responsivity to glucose (Φ TOT), were derived from modeling of insulin, C-peptide, and glucose concentrations

SUBMITTER: Armiyaw L 

PROVIDER: S-EPMC7266075 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature