Another piece of the Zika puzzle: assessing the associated factors to microcephaly in a systematic review and meta-analysis.

ABSTRACT:

Background

Although it is known that Zika virus (ZIKV) infection during pregnancy may lead to microcephaly in the fetus, the prognostic factors associated with this tragic disorder remain unclear. We conducted a systematic review and meta-analysis to assess the prognostic factors associated with the incidence of microcephaly in congenital ZIKV infection.

Methods

We conducted a comprehensive search in Ovid MEDLINE, Ovid MEDLINE (R) Epub ahead of print, Embase, Embase Classic, Web of Science, CINAHL, Cochrane CENTRAL, LILACS, and various thesis databases to identify human studies reporting microcephaly associated with congenital ZIKV infection. We requested primary data from the authors of the included studies to calculate summary estimates and conduct the meta-analysis of the

SUBMITTER: Gallo LG 

PROVIDER: S-EPMC7266116 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature