Suppression of glycogen synthase expression reduces glycogen and lipid storage during mosquito overwintering diapause.

ABSTRACT: During diapause in mosquitoes, efficient storage and utilization of energy are crucial for surviving prolonged periods of developmental arrest and for maximizing reproductive success once diapause is terminated and development recommences. In Culex pipiens, glycogen rapidly accumulates during early diapause (7-10 days after adult eclosion) and it is used to maintain energy homeostasis during the first month of diapause. In this study, a gene encoding glycogen synthase, which converts glucose residues into a polymeric chain for storage as glycogen, was characterized. After dsi-RNA directed against glycogen synthase was injected into mosquitoes programmed for diapause (reared under short day lengths), Cx. pipiens were fed 1% d-[¹³C₆]glucose, and the knockdown effects af

SUBMITTER: King B 

PROVIDER: S-EPMC7266145 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature