5' tRNA halves are highly expressed in the primate hippocampus and might sequence-specifically regulate gene expression.

ABSTRACT: Fragments of mature tRNAs have long been considered as mere degradation products without physiological function. However, recent reports show that tRNA-derived small RNAs (tsRNAs) play prominent roles in diverse cellular processes across a wide spectrum of species. Contrasting the situation in other small RNA pathways the mechanisms behind these effects appear more diverse, more complex, and are generally less well understood. In addition, surprisingly little is known about the expression profiles of tsRNAs across different tissues and species. Here, we provide an initial overview of tsRNA expression in different species and tissues, revealing very high levels of 5' tRNA halves (5' tRHs) particularly in the primate hippocampus. We further modulated the regulation capacity of selected 5' tR

SUBMITTER: Jehn J 

PROVIDER: S-EPMC7266158 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature