Genetic alterations of malignant pleural mesothelioma: association with tumor heterogeneity and overall survival.

ABSTRACT: Development of precision medicine for malignant pleural mesothelioma (MPM) requires a deep knowledge of tumor heterogeneity. Histologic and molecular classifications and histo-molecular gradients have been proposed to describe heterogeneity, but a deeper understanding of gene mutations in the context of MPM heterogeneity is required and the associations between mutations and clinical data need to be refined. We characterized genetic alterations on one of the largest MPM series (266 tumor samples), well annotated with histologic, molecular and clinical data of patients. Targeted next-generation sequencing was performed focusing on the major MPM mutated genes and the TERT promoter. Molecular heterogeneity was characterized using predictors allowing classification of each tumor into the previ

SUBMITTER: Quetel L 

PROVIDER: S-EPMC7266286 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature