A critical re-evaluation of fMRI signatures of motor sequence learning.

ABSTRACT: Despite numerous studies, there is little agreement about what brain changes accompany motor sequence learning, partly because of a general publication bias that favors novel results. We therefore decided to systematically reinvestigate proposed functional magnetic resonance imaging correlates of motor learning in a preregistered longitudinal study with four scanning sessions over 5 weeks of training. Activation decreased more for trained than untrained sequences in premotor and parietal areas, without any evidence of learning-related activation increases. Premotor and parietal regions also exhibited changes in the fine-grained, sequence-specific activation patterns early in learning, which stabilized later. No changes were observed in the primary motor cortex (M1). Overall, our study prov

SUBMITTER: Berlot E 

PROVIDER: S-EPMC7266617 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature