Neonatal diet alters fecal microbiota and metabolome profiles at different ages in infants fed breast milk or formula.

ABSTRACT:

Background

Neonatal diet has a large influence on child health and might modulate changes in fecal microbiota and metabolites.

Objectives

The aim is to investigate fecal microbiota and metabolites at different ages in infants who were breastfed (BF), received dairy-based milk formula (MF), or received soy-based formula (SF).

Methods

Fecal samples were collected at 3 (n = 16, 12, and 14, respectively), 6 (n = 20, 19, and 15, respectively), 9 (n = 12, 11, and 12, respectively), and 12 mo (n = 14, 14, and 15, respectively) for BF, MF, and SF infants. Infants that breastfed until 9 mo and switched to formula were considered as no longer breastfeeding at 12 mo. Microbiota data were obtained using 16S ribosomal RNA sequencing. Untargeted metabolomics was conducted using a Q

SUBMITTER: Brink LR 

PROVIDER: S-EPMC7266684 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature