Plasma phospholipid very-long-chain SFAs in midlife and 20-year cognitive change in the Atherosclerosis Risk in Communities (ARIC): a cohort study.

ABSTRACT:

Background

Very-long-chain SFAs (VLSFAs) have recently gained considerable attention as having beneficial effects on health and aging.

Objectives

The objective of this study was to assess the associations of plasma phospholipid VLSFAs [arachidic acid (20:0), behenic acid (22:0), tricosanoic acid (23:0), and lignoceric acid (24:0)] with 20-y cognitive decline in the Atherosclerosis Risk in Communities (ARIC) participants. Furthermore, this study compared the associations of plasma phospholipid VLSFAs with 5 common groups of fatty acids [i.e., total SFAs, total MUFAs, total ω-3 (n-3) PUFAs, total marine-derived ω-3 PUFAs, total ω-6 PUFAs].

Methods

This study used a cohort study design of 3229 ARIC participants enrolled at the Minnesota field center. Fatty acids were mea

SUBMITTER: Li D 

PROVIDER: S-EPMC7266687 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature